Understanding the Impacts of Chinese Undergraduate Tourism Students’ Professional Identity on Learning Engagement

Under the background of higher education reform, undergraduate tourism students’ professional identity may play an important role in affecting students’ learning engagement and the sustainable development of tourism higher education. Data were collected from 551 Chinese undergraduate tourism students to investigate the potential relationships between professional identity and learning engagement. Based on the theory of social identity, professional identity is perceived as a progressive, dynamic process including professional cognition, professional appraisal, and professional emotion. The data were analyzed using structural equation modeling (SEM), and the findings confirmed that professional identity was in positive correlation with employee engagement. Furthermore, the results showed that professional cognition has positive influences on professional appraisal, professional emotion, and learning engagement, and professional appraisal has positive influences on professional emotion and learning engagement. In addition, the mediating effects of professional appraisal and professional emotion between professional cognition and learning engagement were analyzed, respectively. This study contributes to the understanding of the impacts of tourism students’ professional identity on learning engagement. Both theoretical and practical implications are provided.

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the recent global pandemic. The nuclear export protein (XPO1) has a direct role in the export of SARS-CoV proteins including ORF3b, ORF9b, and nucleocapsid. Inhibition of XPO1 induces anti-inflammatory, anti-viral, and antioxidant pathways. Selinexor is an FDA-approved XPO1 inhibitor. Through bioinformatics analysis, we predicted nuclear export sequences in the ACE-2 protein and confirmed by in vitro testing that inhibition of XPO1 with selinexor induces nuclear localization of ACE-2. Administration of selinexor inhibited viral infection prophylactically as well as therapeutically in vitro. In a ferret model of COVID-19, selinexor treatment reduced viral load in the lungs and protected against tissue damage in the nasal turbinates and lungs in vivo. Our studies demonstrated that selinexor downregulated the pro-inflammatory cytokines IL-1ß, IL-6, IL-10, IFN-γ, TNF-α, and GMCSF, commonly associated with the cytokine storm observed in COVID-19 patients. Our findings indicate that nuclear export is critical for SARS-CoV-2 infection and for COVID-19 pathology and suggest that inhibition of XPO1 by selinexor could be a viable anti-viral treatment option.